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If you want these colonists in your colony it's best if they get that monkey off their back first. To kick the habit just takes time and you will have to deal with their withdrawals for quite a while.
Do not keep any of their drug of choice in your colony! They will break in withdrawals and get at that drug and thus start the whole addiction process over again.
Tynan has a very pleasing risk/reward setup going on regarding drugs in RimWorld. Short term they have considerable advantages but the risk of addiction and just having the more dangerous drugs around the colony is very serious.
I don't mess with the serious ones, but I find beer, smokeleaf and psychite tea to have good uses.
For example only drink beer once every 2 or 3 days when joy is under 45% or 40%.or whatever
Psychite tea once every 4 days when under 35% joy.
Wakeup once every 10 days, at any joy or recreation (to be safe go for 11 or 12)
Ambrosia once every 3 days when joy is under 40% or whatever.
This is beyond the minimum addiction safe intervals and on top of that should keep your colonists from, but this is only to protect them from overdoses. If your colonists start to faint from overdosing, then consider adding a few more days on certain drugs, especially wakeup.
Flake, Go-Juice, and Yayo is never safe, and your colonists may randomly get addicted any time they take these three drugs. I don't recommend giving your colonists any of this unless you're in a last ditch effort trying to defend against enemies, then Yayo and Go-Juice could be practical, but they are almost sure to all get addicted immediately.
As for Penoxycyline, just set that to once every 5 days and you should be good. No overdose problems or addictions for this one.
Drugs in RimWorld are awful.
There just ALWAYS has to be someone online who wants to pull the conversation with argumentative bait. I hope no one else entertains this fool.