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However, with both drugs having the same mass, yayo allows a caravan to pack 50% more value into a single load than flake.
Psychoid tea is worth the least and takes the longest to make of the three psychoid drugs, which means it is only economically valuable to colonies without the means to produce the others. "
https://www.rimworldwiki.com/wiki/Flake
Not sure how accurate this is.
Yayo is far superior for domestic use than Flake is, giving a longer, safer high.
Yayo's effect lasts twice as long and gives an additional movement bonus, as well as giving more rest immediately upon use, is 5x less likely to cause an addiction (1% vs 5%), and 33% less likely to cause an immediate overdose (1% vs 1.5%).
You can find all of this information in the infopage about the drugs themselves and the bill page for producing them. Though for some reason the drug infopage doesn't indicate how much of a mood buff it gives (both are +35)