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Installing it into a living colonist isn't the correct application, nor advisable.
The core is supposed to be used on potato colonists (ie. permanent brain injury with 2 hp left)
never messed with any of these my self.
Unless you have the cryosleep pods, but then it's like one of your colonists died (what I mean is you have on pair of hands less, because that colonist is asleep) , just not permanently but until you get a stock of luciferium again.
Luciferium is almost as bad. Healer mech serums is what you want to cure brain damage. The AI Persona Core implant was added to EPOE a long time ago, before better options existed and the mod hasn't really been rebalanced since.
EPOE AI core seems to be horrific. RBSE I don't remember it having any other drawbacks save the person sort of turning into a skillbot butI'd have to check - that was also in A16, or beta at some point.
(and of course, RBSE and EPOE are non-compatable as they are two different extended surgery mods editing the same whatevers.)
I *think* the mod "more faction interaction" adds a "healing hand shaman" event that might pop up every 2 years or so (on average. Could be more often). If you can get a bulletbrain to the shaman, they are healed 100% of the injury. Since I started having those events I just don't worry too much about it and put people in cryptosleep or whatever till the event pops up.