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The about 6 rez serums Ive gotten (over about 50 games) were all from quest rewards.
It is ridiculously rare
(for me) it seems to be about 1/4 as common as healer mech serum.
I do seem to get them fairly frequently. Have 3 of them in my current game, in 5504. Didn't see a healer mech serum yet.
I got two from quests and one from the Ancient Danger room. Pretty sure you can't get them from traders, unless a mod adds that.
The wiki says freezing them is enough by itself, with all resurrection ailments listed as "the initial chance is 2%, linearly increasing to 80% after 5 days of decay."
The info about freezing and cryosleep both "pausing" the decay timer for res serum purposes was added in May 2018. So that might have changed as of 1.0.
I don't use them very often myself, and I've never used cryosleep caskets, so that's not an article I've ever worked on. Anecdotally it seemed like a frozen corpse that had been dead for a few days was more likely to get psychosis, but I could have just had unlucky rolls.
As it stands the Cult I'm creating has a lot of really old folks in it. Seems more like a care home than a colony. The Lovecraft storyteller can be quite brutal.
They're available only through Mission Rewards or Item Stash Missions, AFAIK. (ie: Mission-only item.)