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It's pretty easy to avoid. Drugs in this game are awful and you should never subject your pawns to them. Situation avoided.
Drugs exist as an alternative way to make money, and as an extra handicap to consider when recruiting new colonists.
I don't expose my own pawn to it.
I do consider it an extra handicap when recruiting new colonist.
Just never expected to be the only occurence I found to be impossible to mitigate after the fact.
My point is that, under the right circumstance, you can mitigate every issue in this game.
Exept this one (or I haven't found it yet ^^) who basically seem to be just a "oups, rng say you die now".
but again, downside is their time is limited, so often they will spend time in a cryotube if not otherwise required.
It's not RNG, or impossible to mitigate. Colonists die when their consciousness hits 0. Having chemical brain damage reduces the effectiveness of their brain (-50%) meaning they have drastically lowered consciousness, stack consciousness losses from other sources like withdrawel and pain and a colonist can hit 0 and die. Wake-Up withdrawal on a colonist with chemical brain damage will be fatal because the withdrawal eventually hits -50% consciousness as well. There's nothing random about it. There are ways to counter this, but it's not easy because chemical brain damage is a very late stage affliction caused by severe drug abuse. You aren't supposed to let it get that far, if it does there is luciferium and healer mech serums.
And that is why I say it was random.
As you said, it is a very late stage affliction. My understanding was that it occur durring or right after heavy drug use.
Apparently, it doesn't matter and can occur even later on even if you stop using (like in RL i guess but gamewise I found this dunmb ^^).
I would have understood if I had used other drugs to relieve the mood debuf or if the colonist got sick on top of the withdrawal or any other incident who would have lower her consciousness to 0 in a way that either make more sense or is theorically mitigable in some way.
But whatever ^^