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They are also separate from Spacious Environment and things like that, so just making the place look nice is good enough.
Food Poisoning is more likely from dirty floors, but mostly from poor cooks. A cook of skill 0 will nearly always make food that gives food poisoning, but higher is far less likely. I think by about 6 or 7 skill it becomes very uncommon.
If you're not seeing food poisoning, it's probably because your cook is very good.
Room cleanliness has a fairly high potential effect on food poisoning chance. I don't remember off-hand, but if you click on the stove and go into details it might give you the actual impact of the current room cleanliness. I know it does that for research tables now. Even a skill 20 cook will spit out meals that cause frequent food poisoning if made in a really disgusting room. Like if they start cooking in the same room as the butcher table, right after butchering an entire tribal raid, with none of the mess being cleaned.
So the skill level seems to be the most important factor for poisoning, ofsetting the negative cleanliness by a big margin.
A skill 20 cook still has like a 0.1% chance to food poison, and in my experience an unclean cooking area can multiply the chance by at least 10, causing low level cooks with a 10% food poison chance to poison nearly every meal, and skill ~15 cooks to poison like 5% which in a colony of 10 eating 2 meals a day means somebody is getting food poisoning almost every day.
We don't know for certain how much of an impact the value has, my experience is it's quite high but there could be a lot of RNG skewing things. We know that the stat exists though and it's a legit mechanic, the wiki mentions it briefly and the definition of the stat can be found in the game xml:
<RoomStatDef>
<defName>FoodPoisonChanceFactor</defName>
<label>food poison chance factor</label>
<workerClass>RoomStatWorker_FoodPoisonChanceFactor</workerClass>
<updatePriority>0</updatePriority>
<isHidden>true</isHidden>
<defaultScore>1</defaultScore>
</RoomStatDef>
Somebody would need to look at the code to see the exact effects, and AFAIK nobody has bothered to yet.
Like others have said, mainly pawn cooking skill and health is the main factor. Stuff like comfy chair, room stats, and pawn mood is kinda uncertain for me. I've never bothered testing since food poisoning is only lethal for pawns with really low conciousness. Pawns that are trying to cure multiple drug addictions, pawns just before and after surgury, and pawns in extreme pain a great examples.