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That video above will probably goes into detail about the benefits but as an overview if we consider a few skills from the alchemy tree combined with a few decoctions.
The Arch Griffin decoction makes strong attacks consume all stamina but reduces the enemies health by 10% after their normal damage is taken. The Ekhidna Decoction heals you whenever you perform an action that uses stamina. If we take acquired tolerance (Increase the maximum toxicity based on number of owned Alchemy formulas) we can use these simultaneously.
That means that whenever we hit with a strong attack we deal a ton of damage but also heal ourselves. If we then take tissue transformation we gain an additional 1000 hp per decoction consumed if memory serves. If we combine this with school of the bear heavy armour, we are literally a tank.
Now to make things more interesting we can take refreshment that allows any potion used to heal us as well as perform its original intented effect, this gives us emergency healing and just makes us even more tanky. We can then take Protective Coating which reduces damage by 25% from opponents if they match the type of oil we apply to our swords. Now we are even more tanky.
If we spec into adrenaline we can take undying which resurrects us with adrenaline points if we die. We can also take Flood of Anger which allows us to use max level spells using all our adrenaline points. Some people may take Razor Focus instead of one of these, as i said I wasn't min maxing.
We now have a few more options. If we spec into bombs and take Efficiency we carry more, which i found very useful when you have high level ones. We can also if slots permitting take cluster bombs which means that bombs fragment and cause multiple explosions.
Regarding Oils, we can take Poisoned Blades which adds damage over time and Hunter Instinct which increases critical hit damage when we have high adrenaline.
If we combine the above with adrenaline rune stacks in our equipment, we rake up adrenaline to do more damage, can use powerful spells and if for some reason die, get brought back to life.
I personally specced a bit into fast attacks to get whirl as imo some enemies are better dealt with quick strikes.
So yer, it was pretty damn good overall and hardly ever died playing on the higher difficulties, you literally become a drugged up demi god. Hope this helps :)
Yah lol Alchemy is tooo powerful lol. Haven't tried it with bear armor yet. I have been using a mix of witcher and normal armor and I'm still tanky lol
Anyhow, I have around 15k HP on deathmarch NG+, level 57. Running 3 decoctions at once, healing myself by using Quen and the like, and stuck smacking stuff down with Heavy attacks or Whirl. Basically the best build; there is nothing better to what I've seen.
The armor enchant from Hearts of Stone to deflect all arrows is a god-send, by the way.