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It was an easy boss which I killed on the first try, I don't remember what I did specifically because of that. For the next boss I needed to retire and come back later, it was more difficult.
And thats before factoying in any buffs from Synergizer, if you add that as well, I might ad.
Potion's 300/sec for 20 seconds becomes 300*1.1^15=1253/sec per 20*1.1^15=83 seconds at level 15.
Alchemist's cowl gives 1+(0.2*1.1^15)=1.83x to both poison damage and duration.
Total becomes 1253*1.83*1.32=3026/sec per 83*1.83*1.1=167sec.
That's 505342 damage.
Add Frailty for double that damage.
https://steamcommunity.com/sharedfiles/filedetails/?id=3257608016
So it's 1m damage if they all trigger correctly - frailty and potion first, poison explosion next. If poison explosion triggers before frailty or after normal poison spell and before potion, it may result is smaller damage.
In normal farming mode when I don't use alchemist's cowl or synchro board it is
1253*83*2=207998, well, almost 300k damage. I must have remembered the value which I checked when I wasn't really in the farming mode and forgot to switch the board.
Level 15 gives 1.1^15=4.18x multiplier.
Assassin's Baselard (level 0): -15% attack delay, 15/sec for 1 sec
Assassin's Baselard (level 15): -42% attack delay, 63/sec for 4.18 sec
Assassin's Cloak (level 15): 400*4.18=1671%=x17.71
Asssassin't Baselard (level 15) with Assassin's Cloak (level 15): -42% attack delay, 1116/sec for 4.18 sec
Dirk of Ruin (level 0): -30% attack delay, 300/sec for 1 sec
Dirk of Ruin (level 15): -64% attack delay, 1254/sec for 4.18 sec
Dirk of Ruin is better according to math (higher speed and higher damage) and it requires 1 less accessory slots. It's harder to craft though because Baselard unlocks much earlier and so it gains more extra levels during transmutation. But at max stats Dirk of Ruin is better.