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This may sound weird at first and part of my brain was very "nah that can't possibly work" but I've seen "unbalanced" builds work in other types of games. And also, the series where my avatar's from. That build shouldn't work, either, but it does.
Anyhow, I was stuck trying to get Eternity challenges done to speed things up, challenge 2-5 and challenge 4-5 were kicking my rear and I was nowhere near getting close to the goals with balanced lab points distribution, last I tried it took hours to get 1k closer to the goal in 2-5 and the goal was still several hours away. Changing the lab points to 100/## on gen/common exp let me complete those two challenges in less than one hour, instead of the previous "a dozen hours just to complete one of these" I was looking at. It also helped me get three more layers of Super Nova, so that's nice too.
How long did it take you to get to 48 animals? I feel like there was an update, that changed to lab multiplyers, since IP is x1 mio better then the recommended ratio, but still very slow at 26 animals atm
You still would want to switch to a #5/6 ratio for score to buy AP, Supernova, and challenges. Common ratios that can vary 1:1 through 1:4. Too many variables to say which is best for each player.
It is only around lab level 400 (can vary depending on animals bought, supernova, challenges, etc) where #5 and 6 can gain better EP/s with longer runs. The ratio does change at different times. Eventually during Dilation Tree it is all pts into #6 (which is also better when doing early dilation score runs and some Eternity challenges).
This is true as of game version #0.225 and I don't think it changed in 0.226.
I'm constantly having to test my ratios for lab 5 and 6 for max EP/s before switching build for Dilation (all in lab 6). There's a point where putting too much in lab 5 actually works against building EP for upgrades. No idea why. I'm at Supernova 40. I probably should have started checking ratios earlier in Dilation part of the game.
At that stage in the game the lab ratio for #'s 5 and 6 is most likely either 1:1 or 1:2
This talks about the ratios as you progress through the game, I've been using this guide whenever whatever I'm doing has stopped working. It's been invaluable to my progress.
As said in the other posts, it depends on where you are in the game.
If I had to summarize it, I would say
early game is 90:10 AP:EP
midgame (defined by specific animals you've gotten) is where you start with bottom 2 in some ratio. 1gen:10common at the start and reducing that for the sweet spot.
endgame is basically where you go all in on common due to the bonus research points. My endgame state was 100% common and that was 30,654 bonus on everything and +16,420 to common. I disagree with the guide saying go 1:1 at the bottom, if i split it to 8000:8000 its simply slower