Logitech G910 Orion issues after starting a game

[Krunchy Brain]

Has anyone had a problem when you start playing in a game then some of the keys stop functioning like they should? For example when I play Overwatch my ESC key will not pull up the normal menu and when I hit tab it automatically goes to switching windows.
I don't understand what is wrong? I have updated Logitech software, ran a virus scan, reloaded Overwatch, and moved USB ports. The problem has also happened in Final Fantasy 14 but everything else is fine. Has anyone else seen this and if so how did you fix it?