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In fact, most of my characters since then could have easily defeated him in one go. Once you get those building bonuses and realize you have to go for Relics as aggressively as possible, you become real strong. I typically beat Act III bosses in a couple turns, sometimes one, sometimes three.
I haven't fought him again since finishing the first time but curious how it will go with other builds. Sounds like you build much more aggressively than I do, I definitely don't kill that fast. I focus more in block and buffs with only 4 or 5 attack cards.
And no, i dont think anyone can kill it in first try, because beside it drain your Sanity, it will put a lot of curse card on you and also exhausted your card as well.
Back in the early game I played quite defensively too. With only 3 Energy, that's basically the only way to play.
But with bonuses unlocked, aggressive play suddenly becomes highly viable. Some decks I just had a few Shadow Strikes and Secret Plans so I could generate a bit of Block while I attacked, others I just had a couple Play Deads (it's Repeatable so you can dump all your Energy into it, generating a huge amount of Block).
Recently I even went for a Blindfold build, full of high-cost cards, randomized to 0-3. Turns out, when you Thompson Gun three times in a row and then unload the rest of your Energy into a Shotgun blast, all on Turn 2, you do a lot of damage. Especially when you cast a few 3-cost (but actually much cheaper) Offensive Reflexes on Turn 1. You'd stay in Frenzy mode all the time, too, it's just that all enemies are dead before you can get that going.
I agree 100% on stacking Relics, and they really encouraged you to with the set completion mechanic. I would sell equipment and consumables to make sure I could get 1-2 from merchant each time, besides the obvious museum.
I was a bit disappointed, as I not only beat Cthulhu 1st go, but my first time as the Professor. I had all starters unlocked so I used the crow deck, so logically went minions/poison, the boss eventually taking over 100 damage per turn. I had less than half the base unlocks ffs.
I'm sure there was some luck involved. I had completed 3 sets, and had card holdover. I had 3 abilities at level 3, one of which was to regenerate 1 sanity for 1 insight. I was regenerating 4 insight per turn and could handle anything on any turn.
Lastly, I noticed I had very little building materials that run, which though I didnt do this on purpose, made clear what should have been obvious. These don't help you at all in your CURRENT run. So anyone struggling might want to forego the long game when trying to make a strong build. You can refuel less and gain more $$. Elite fights, Museum, Merchant, make sets. 3 rows of relics and I would have passives going off I forgot I even had.
And your investigator STILL ♥♥♥♥♥♥♥ dies, lol...
You can choose to play with premade decks, all building bonuses disabled, fuel mechanics enabled, fewer cards before the boss, more monsters per combat, Cthulhu as the last boss, etc.
If you don't find that challenging, then you're a victim of your own extreme competence.
Once you understand the boss, at least with the Professor, it is possible to beat him without needing many relics
With added cards before the boss, probably.
With fewer cards before the boss, it would be much harder. That's 12 fewer events to get stronger before Cthulhu.
And that's only with a really strong anti-Cthulhu build.