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At the end of the day, she was intentionally designed to be a weak combatant who you take along for gold primarily, hence you don't build comps around her as a core (ie. hence nobody really synergizes with her in the right way). Instead, you form a strong trio and ensure that the ANT (as the spare wheel) doesn't make their life harder.
The only real synergy is Riposte (HWM) as her Protect Me can provide him with a little defensive pep and give him a higher chance of capitalizing on it. As a main-healer, she would need to be in R4 or R3 almost exclusively, which is something the HWM can help with (and has no noteworthy positional restraints, making him easy to fit into an above-mentioned trio).
Some would say MAA, but that only applies if you're going for a dodge-strat, which I'd avoid like the plague outside of endless mode, and I avoid it even there. Having both provides Guard and Inverse-Guard, but they don't overlap, and there shouldn't be scenarios where you're using both those skills together.
Despite the fact that she has a blight-res-strip, blight-comps simply aren't a patch on bleed-comps. PD is a force all by herself and doesn't really need help. GR is not a great dedicated blighter when considering the rest of her kit. An ShB would rather be Piercing, and an ABM would be better served stunning. Having said all that, you could probably make ANT-PD-ABM-SHB work, but it's not how I'd go about it. I definitely wouldn't take a GR just to have her throw Blight Darts when she has Lunge and TDagger on the table.
Honestly, so long as the core trio work well -- preferably with plenty of stuns to make her sustain-job easier -- you can get away with having the ANT there, regardless of whether she compliments them or not.
OP mentioned main-heal ANT, thus having a VES there kills the concept. Having both and swapping their roles isn't a good trade, so you'd typically end up just healing with VES and having ANT spew Vapour 24/7.
Of course all this buffing murders your offence, and riposte conflicts with stun. Stuns are better. Sure your damage output is actually higher than a non-ATQ party, but you're taking vastly more damage and you can't focus fire, meaning it's still an ATQ party and thus still the only kind of party that's beaten by leper parties.
The reason festering has -blightr on it is so that you're not forced to take a +blight trinket on the ATQ. However, this means the blight takes two turns instead of one, which is 100% more turns, and that's only if you make your debuff check.
Without DLC you can't make a non-degenerate full blight party. You need SBR or the CRU's madness trinket.
For some reason Red Hook is very fond of self-synergizing heroes. BH's pull mark synergizes only with another BH. Lunge is especially good if you have 2-3 GRs. Solo is kind of bonkers if you have three jesters. PD's plague grenade is amazing, provided you have a second PD for spamming blinding gas. CRU has reach as long as you have two CRU.
Likewise, if you have three ATQs for whatever reason, they can debuff blight resistance for each other.
VES, HWM, CRU, ANT
ANT, HM, MAA, OCC
The first one works really well in ruins, and you can do even long champion dungeons with it. It is a "protect me" build. Just go riposte turn 1 with HWM, then protect me with ANT, holy lance with CRU and Stun with VES. In this one, it is very important that the HWM have higher speed than the ANT (That way you can protect me turn 1 and then do another thing on turn 2).
The other one can work everywhere, early is worst but in the late game you have a way to deal with stress, remove PROT and stuns.