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tl;dr make things not alive fast and is really fun
I never have and never will understand why people still think this way. That mentality only applied back in the pre-expansion era. It doesn't apply much anymore, less so when discussing versatile heroes like the Fla. Ruins are still choc full of bleedable enemies - farmstead version being no exception. He's also a fantastic stress-healer and a decent off-healer, though that is limited with the per-battle changes. His impact damage can be improved, and goes up naturally when injured (which, in endless, he often will be). You also have no choice regarding swaps - a sizable chunk of heroes have their own problems in X or Y region.
Doesn't really matter. They helped, but weren't necessary. Farmstead is one of the few places where a Leper can actually do solid work, though it's a shame he won't get as much use out of Revenge like he used to. Also suffers tremendously if shuffled - has great move-res but the possibility is still much higher (and sometimes unavoidable if you start encountering fights like the Shambler, or even Crocs who start pulling people forward and pushing Leper backwards.
Crusader is a great utility hero who has mobility on-demand for the wealth of situations where shuffle will be a problem. He's pretty much the best alternative to the Jester for pure stress healing (in competition with the Fla). Just like your concern about bleedables, his best damage is against Unholy (of which there are plenty), but again, you can't bank on what the mode will throw at you. Despite that, CRU is a solid choice outside of being obnoxiously slow.
Required, no - but unless you are going to use full-on cheesy strategies, you're going to need decent stress-healing - and he's still the absolute best at it. His bleeds are relatively decent as well. A Jester and Fla together is crazy-good stress-sustain and compliment eachothers bleeds, for example, even if neither have the best impact damage.
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Classes I would recommend:
Vestal - obvious reasons.
Jester - obvious reasons. His battle-ballad is also super-good for endless.
Crusader - decent projection/mobility in a pinch. Possible off-healer, full-on stress-healer and a decent stunner. Best used if he's one of (if not the ONLY) slow hero in the team.
Shield-Breakers - piercing, blight, projection, on demand protection. Some may prefer using a GR instead, but SB has better on-demand projection, better blight, higher pierce, equal (if not more) health and a more reliable defensive tool.
Highwayman - mobility + riposte by itself is invaluable in an endless setting, plus bleeds and being a pretty meaty/healthy DPS.
Flagellant - great sub-shealer. Jester could do it by himself, but having more helps. If you're having a Crusader take on that role instead, you'd do well to have a Fla helping him out. Best bleed in the game and plenty of trash and bosses that are weak to it. Can heal in a pinch.
MAA - tend to avoid them, but their protection, stuns and buffs can be very useful. Damage isn't the worst either. Has been a fundamental part of cheese-comps in the past, some of which still apply.
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Classes I would avoid:
Arb/Musketeer - shuffle-weak, slow, great off-healer but positional restrictions and being optimal with marks makes her awkward to use).
Graverobber - can be made to work pretty well, but she's still the lowest HP hero in the game (along with Jester) and doesn't do anything a SB can't do (other than stealth-shenanigans, which you don't want to be wasting too much time doing [and is not guaranteed protection]).
Abomination - can also work but his steroid mechanic goes against the mode itself and can cause issues unless you're super careful and packing good answers for stress. Can fill the stunner role but you'd often want something with a bit more pep while holding back on his main damage source. Also suffers in P4 (either form) and P1 (human form).
Occultist - great for off-healing, not too shabby at damage and still one of the best ST-stunners in the game, but also squishy and won't contribute anything that others can't do without his concerns.
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Won't list every class into every bracket but above is a good start.
I know I can push 400 and higher with my original comp (VES-JES-HWM-FLA). Others like PDs & HEL (double-stuns for front and back), or Leper burst-comps and other things I've no interest in trying, so no doubt other people have other suggestions.
Your best option is not to look for people to give you a comp directly, but to experiment and find what works for you VS what you intend to achieve from endless.
No problem at all. In that case you have some more freedom. It's when you're trying to push into eternity when you'd have to be a lot more strict with your comp. For the 300 achievement you can flex a bit.
I would recommend simply starting with the VES & JES as a baseline. You'll find the majority of comps will adopt them for the best healing and best stress-healing and are a good basis for standard comps just looking to go for achievements or light shard farming. From there you have to decide whether you want more burst, projection, bleeds etc. They can fulfil the healing and shealing functions by themselves (with the VES as an off-stunner and sniper inbetween), but having more sustain doesn't hurt (especially stress), hence the FLA would be a decent choice, or a Crusader (but not together if you already have a Jester - you don't need three stress-healers).
FLA would be Punish, RoSorrow, Stress Heal and Redeem for the most part. Cru would be Stunning Blow, Lance, Stress Heal and either Smite or Bulwark (for as long as you can use it). VES would be stun, judgement, and both her heals. Jester would be Dirk, Finale (for bosses), single-target bleed (for trash), battle ballad and stress-heal.
Again, my initial comp was VES-JES-HWM-FLA (which I took for fun to test it out, thinking it wouldn't get too far). Turned out they pushed over 440. Seeing as I only wanted the 300 I basically went on auto-pilot after the achievement and didn't care what happened from then on as I already had all the shard-trinkets I wanted. Haven't needed to play it since, even though I know I could do far, far better.
HWM+Jes ensures you have two answers for shuffle, constant buffs, more bleeds, and Riposte (which is insanely powerful in endless, especially against bosses like Miller, Sleeper, and the majority of others). Shield-Breakers would be a good choice for projection, pierce and additional shuffle. Flagellants for more sustain (HP/Stress) and bleeds, Cru (same reason, plus mobility/stun and minus bleeds).
Houndmasters are solid due to self-sustain, projection, good stun (up-front) or additional stress-healing (backline) if desired. Can even take Guard if you absolutely want, but I tend to avoid using them in endless.
Man-At-Arms is a good choice if you want more buffs/stun and protect/tankiness, but not if you need more burst or projection.
Plague Doctor, Hellion and various others are also worth consideration, even risky heroes like Grave Robber if you have the right comp to keep her in the game.
Will leave the rest up to you - you'll get there with practice and experience, just have to choose how you want to go about it.
Have fun!
One of the major issues with long runs is diseases. Some are run-enders. For instance, The Worries is a big one you get from Ghouls often, and this becomes completely unsustainable especially if you hit the Unbearable Reflection at 200, and even more so if you already have a critical +stress trinket (these should be avoided to some extent although Jester has a couple nearly necessary ones).
Similarly, things like Hysterical Blindness can completely ruin a run.
(And of course there are things like Rabies which is nearly meaningless in Endless runs and arguably actually a buff, but you don't care about those.)
So PD fills a very useful role in long runs because he can get rid of diseases. GR even more so, but for obvious reasons is a squishy and tough to avoid the inevitable bad luck. By comparison, PD is quite nice with melee and can handle herself at R2. A few doses of Battle Ballad and she's a crit machine.
To a certain extent you can hold off diseases with Holy Water, but you run out of that.
(There's also the alternate method of just bringing Cursed heroes but this is obviously subject to the same running out of supplies issue, burns through a lot of Blood, and as much as I love Bloodlust, you really don't want random things messing up your routine in long runs.)
So you're saying you don't care about -20 ACC. That's. . .a very special opinion.
I never take PD's or GR's to endless and it has never impacted my ability to push comfortably into the mass hundreds. Going further than that is merely bragging rights.
So no, I don't care about diseases and I don't regard that as any kind of 'special'.
My attitude would be much different if it was generic play or something with more impact, as opposed to a mode where weeks do not pass and you can repeat it as much as you please. The ratio of disease-capable monsters is quite small - the majority of which can be blown up 9/10 of the time. The only enemy I would have any concern about is TTFTS and his awful Sky Taint.
You would also have crit-buffs, ballad, trinkets and other effects that would lessen the impact of such diseases. I have even experimented with comps/heroes using absolutely no accuracy assistance at all, to which some of them may as well have started the run with -20 Acc, eg. Crusader using blight-sword and stress-healing power. Him having 0 or lesser accuracy is somewhat moot when the ability you are going to be using for 95% of the run doesn't even need it.
What they give you is pretty terrible, though. Ghoul gives out the Worries like nothing, and that's a straight +30% Stress.
As an example, I got Grey Rot, the Worries, and Hysterical Blindness on a Leper. That means any two stressers hitting him and any added +Stress debuff brings him from 0 stress to a Hysterical Blindness -20 ACC in a single round.
If you add +30 Stress to +10 from some Ancestral (I like to use Ancestor's Pen on melee guys), then throw in another +10 from Haunting, and another +33% from Unbearable Reflection after 200 kills, and it's completely unplayable. You just have to quit.
Never mind just the pure useless of a Leper with -20 ACC.
I also never bring GR (just too flimsy) but PD is actually quite good. I don't do it every time, but any time I get deep, I end up with diseases that are seriously bad after 200 kills. With PD, this just doesn't happen, they can be handled as they infrequently show up.
It'd take some impressive disease combos on a lone individual to bust any/all relative counter-buffs and render them useless. Worries is awkward, sure, but he is also a size-2, meaning you will always have freedom to stun him whilst bursting him down. Given I typically run bleed-comps, one stun into bleed-stack will ensure they are dead shortly after (ie. their prot is irrelevant), or worst case scenario, get a howl off but then be so bled-up that they can't cast another. It was not uncommon for me to casually melt double-ghouls with little to no risk of them howling at all, and there's only so many combos where his size-2 + 2 [insert mobs here] prevent you from keeping a ghoul in check.
Not getting diseased is better than getting diseased and having a cure for it, though I say that knowing you can't always prevent it in that manner, just that it is extremely unlikely for me, thus I don't value the cure over just streamlining the comp in other ways.
Considering said bleed comps also typically involve a Jester with anti-stress and potent sheal, I won't cry if one gets the worries. Same applies with accuracy - if trinkets and battle-ballads can't cover for an ACC deficit of any description (disease or not) then that disease is not the real problem.
As said, the only concern I would ever have is TTFTS given it is essentially an un-burstable boss who is extremely likely to apply Sky Taint. Not that I fear the disease, just that it is the most likely scenario where one will be acquired no matter your approach (without disease-res) - and at +20% stress and weakness to bleeds & blights, that is far less pleasant than a hero losing a bit of accuracy, or just the flat stress of the worries.
Different strokes, different folks. I'm not bashing the use of PD/GR for that purpose, just stating how little I value it (and that I resent it being called a 'special' opinion). I don't treat endless even remotely like how I treat standard dungeons.