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You can tweak your skills on the bar so you only have one reasonably good attack and three skills that will be useless to the Siren, like weak self-heals/de-stresses. That increases the likelihood of your captured hero being useless, while still maintaining enough combat ability to output dps reliably.
In addition to the heavy damage dealers, Occultist can be a real PITA if he gets some crit heal that more or less brings the Siren back to full health after you whacked her down for several rounds.
Well, that's good to know. I haven't seen them use non-selected abilities but I guess I got lucky.
Their trinkets:
PD = Recovery Charm (+40% healing received), Speed Stone (+1SPD)
V = Sacred Scroll (+10% stress, +33% healing skills, -10% stun skill chance, -33%DMG), Ancestor's Scroll (+25% healing skills, +25% Stress skills, +10% Stress)
GR = Recovery Charm (+40% healing received), Quickening Satchel (+2SPD)
A = Bloodcourse Medallion (+33% Healing received), Candle of Life (+50% Healing skills, +15% MAX HP)
That must have been the easiest siren I had ever done!
I even forgot to use my holy water for the fight. The siren uses her song of desire on my Antiquarian 3 times and on my Vestal 2 times. Meanwhile, everybody else out there were stacking blight like crazy!!!
I'm just so hype and happy to have beaten the siren! I hope this setup focused on healing and low damaging heroes while help someone else out there! :)
The only other real thing is bring along antivenom/bandages for whatever your dot(s) are.
And don't throw on +CRIT battle buffs and similar stuff. Leper is usually best avoided but I've brought him without too much pain.
If I really want her dead I stun the guy who gets charmed. PD/BH/HEL zero damage stuns ftw. The AOE stuns are also a plus.
Siren is in the lower bracket of difficulty in terms of bosses - one of many that love bleeding twice per round and relies on a managable gimmick as its only real threat. 90% of the cast that get seduced (if at all - seeing as it can be resisted via debuff-res) will often use party-buffs or non-attacks rather than turn on the group. It is always amusing seeing Jesters, Crusaders, Flagellents or other cast members stress-healing a Siren, or standing there using self-buff mechanics so that they're buffed up when they return to your party.
Pump bleeds into the siren and kill spare adds when appropriate. If you genuinely fear being smacked by a party member, you can stun them, but most of the time I just let them do their thing seeing as the Siren herself typically spams AoE stress or AoE light-damage bleeds rather than burst to follow through seduced damage. Assuming you have stunned or slain additional adds that get summoned, chance of being deathblowed is slim unless you've let the fight go on too long - which it won't, because bleeds. Bleeds for days.
They have all their skills, whether chosen or not.
So avoid buffing CRIT and DMG excessively, and if you use camping skills, choose things like stress relief and -stress and resistances, things that don't help the Siren if she gets them.
Like other people have said, if you focus on a bleed or blight DoT strategy, her charm shouldn't be much of a threat to you.
I've even had her do Leper twice in a row and not suffered for it. There's a reason she's considered one of the weaker bosses.
A dodge party based around Antiquarian can be pretty good too.