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Or a Crusader. That whole boss fight is basically about the stress management.
With a rank 2 hound master and some Stun trinkets you can easily do so a majoiriy of the time
If you have a Leper in a fight like that, it's for the simple fact he can AoE the front-rank (essentially allowing him to damage both the boss and the extra enemies simultaneously). It is the only worthwhile reason, hence he is a viable option for bosses such as the Crew & Pounder.
Why would you even bother letting them get stressed to that point anyway? You're essentially dedicating trinket slots, positional priority (in a fight where heroes can be shuffled + a hero who really needs to be in P1-2 at ALL TIMES, P1 most of all if you are aiming to have him get anchored), and all the other risks involved >> when you could just hit/kill/stun the damn thing.
Abomination's Rake attack also does this and without the necessity of having a filthy, worthless Leper (minus the Heave To resistance of course but you can load him with virtue trinkets if you like).