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CC is all fixed maps too, much like DD itself, other than blood gathering missions and a repeatable trinket farming mission with a weak boss you get after the Countess.
There is no particular reason to finish locations in any particular order, and perversely, most of the Trophy trinkets are absolute junk, with only one god-tier among the bunch, Prophet's Eye. And Prophet's Eye is the only general ACC trinket, and even it only works in the back row. Still, if you get it, you should almost always put it on whoever you have in back.
The only other ACC trinket in the whole batch is Vvulf's Tassel, which only works against marked, so really isn't that great either.
Many of the rest are "best in class" for specialties you don't usually care much about, like Flesh's Heart for bleed resist, very nice for a healing Flagellant and not worth much for anyone else outside of CC missions, maybe, Hag's Ladle for blight boosting if you actually want that, and the only blighting characters you care about already have their own trinkets for it.
So other than (maybe) Prophet's Eye, there's no point in choosing regions solely based on killing the bosses in them.
The main reason to focus on specific regions is the Heirlooms you get, because finishing the blacksmith, guild and stagecoach is what you really want done as fast as possible, and this means mostly farming Weald and Warrens. I find myself neglecting ruins as a result at least until after that's done.
On the good side, Weald has two of the better trinkets, Fuseman's Matchstick (a nice ranged trinket) and Hag's Ladle (meh it's sometimes useful), and Warrens has Wilbur's Flag (okay on a healer you don't want stunned or some already dodgy hero like Jester/GR I suppose) and Flesh's Heart (FLA or I suppose someone in front on a Cove mission with those damn crabs).
In general, though, everywhere that isn't DD itself is just a trinket/heirloom farming area and bosses are very low priority.