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And while i'm on the subject is rabies +dmg something to get, or does needing the +acc trinket make it too much of a burden?
I already find Hellion needs an ACC buff (Heaven's Hairpin is a nice one) and the Fits basically knock it out.
I usually don't leave on any diseases even the semi-ok ones but it would also be okay for some hero you intend never to attack anyway like a healbot. Thing is, I usually don't do that, even my Antiquarians usually hit sometimes, and if I have a slow healer I'm okay with them being slow anyway. They can apply heals at the end of a round before the next starts, instead of healing someone off DD just for them to get hit right back to it, then hit again by some fast enemy that rolled high.
Only very rarely. There are usually only terrible diseases that are a priority to get rid of immediately, or ones that are livable, and if you have to heal just one, you'll pick the high priority ones.
Another of the semi-bads is Rabies particularly in Endless mode where its debuff is no big deal. Similarly, Grey Rot a -ACC/DMG disease that boosts HP, and you couldn't care less on a pure healbot. Another example would be Grey Rot on an MAA in the back row (the Guardian's Shield) thing. These are both really niche, though.
In general, any -ACC makes me want to rip my eyes out.
I work from the clean-slate and judge what is needed from there, which also makes it a lot more easy/predictable when dealing with debuffs, stress-relief issues, curios etc that sully the numbers in different ways. This would be different if you could only have one disease (hence it would be beneficial to cherry pick one and try to keep it above others), but seeing as they stack, I'd much rather just NOT have to even consider them.
Not saying it doesn't have merit, just that I don't entertain them during my playthroughs, which is ironic as someone who puts very low value in having in-team disease cures.