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I've had a jester in that fight many times with no real issue. He can more or less guarantee the SBR doesn't get afflicted.
PDs are god-tier as always. You can also bring all the bandages and antivenoms, but then it's a waste of money if the nightmare doesn't proc.
In the fights with more than one Pliskin that might be useful but ARB/MUS are pretty slow. It's going to get in one hit before then, and if it's in front, which it probably will be other than in that one encounter with four of them it will have a super high chance of critting, and luck usually has it that the crit's on the SB who is already taking massive stress.
I usually want SB to have the de-stealth ability and use it on the Pliskin then finish it with someone else. Quickdraw can make this happen. If the first act destealths one of these and you can finish it with another 1/2 hits, that's the worst of the fight already over. While they're heavy damage dealers, they're pretty low HP and easy to kill once their stealth (and massive +CRIT buff) is removed.
I tend to no-brain all nightmares with JESTAL every single time. I mean, why not? Best healer and best SHealer in a fight with guaranteed stress for at least one hero no matter what you do, and likely chance of passive riposte damage and/or DoTs.
In short, I usually just roll with VES-JES-???-SB
FLA - usually my go-to for Nightmares. His bleeds wreck snakes, he's a stress-healer (great with another stress-healer if you want to hard-nuke SB stress), he's an off-healer (if you take damage for some reason, one of which [exanguinate] will often annihilate snakes outright), and if they hit him he just gets better/faster at killing them.
LEP - just have him hew everything. He doesn't care about snake riposte thanks to being the meatiest meatsack from meat hill, and his self-sustain (if needed) gives DoT res if you're worried about blight. Assuming you can provide him with proper stats, you're almost guaranteed to not have to even throw maintenance his way, leaving you free to tend to the SB or others while he just farts around waving his big stick.
CRU - similar to above, except he is also a stress-healer. I'd plop him out back and have him lance his way to glory before resorting to stuns or stress healing by the time the board is clearing up.
HWM - bleeds and his own riposte. Besides, with an SB guaranteed in the party, it helps to have an additional shuffler to help keep each other in optimal positions, or even push certain people back out of harms way when the opposing side has been thinned. Given it's a fight on a soft-timer, he's one of the better damage dealers in the game, thus always useful.
HM - great stun. If you don't want to waste turns bypassing guard, just slap those slitherer's upside the head with a blackjack and let the SB go to town. You can opt for full-team AoE/bleeding if you already have bleeders (and to get damage rolling on stealthers you decide to leave hidden, so long as there's at least one attackable target). Can guard if necessary. Failing that, you COULD have him as a replacement Jester for stress-healing, but that's not exactly effective when you're mostly going to be worried about one hero (rather than the whole team), but it's an option.
ARB/MUS - I tend to not bother, but I would take them for fun now and then. Sure, if you want to be super timely then you can drag the flare along, but I'd usually just have her spamming quickshot to become the fastest shot in the west and then have her abuse guaranteed first-round damage to dunk whatever is a priority or finish whatever my other heroes had been slapping. Failing that, she can off-heal.
Most of the rest I don't bother with, but you can make ♥♥♥, BH, HEL and various others work perfectly fine.
So maybe a couple Gleeks get off in the first/second round but the high priority front ones get killed.
@Rope Drink Not in general, just the fourth and seventh ones because they rely more on mass Stealth (4th) and the "oh noes, twin Size 2s" fear factor (7th), as opposed to the balanced composition of the other ones, to trip up those used to nightmares, but still playing the specific comps blind, up to that point.
Good shout to those mentioning JESTAL--amazingly, in the two times I've gone through these nightmares and completed the set, have only occasionally brought a VES along and have never used a JES, to my recollection. Madness.