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https://steamcommunity.com/sharedfiles/filedetails/?edit=true&id=2266077934
If not then go to your subscriptions in Steam and sort them by Date Updated. Look at what has updated since you started having problems and try removing them one by one, test to see if the options save, restarting the game between each test. Keep going until you find the mod causing the problem.
If the only update in that time is TMPE, then the update has likely caused it to be incompatible with an older mod of yours, which will take some more digging to find.