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I only defeated isaac once satan 3times
look for tinted rocks
ez game
Angel meta is extremely helpful since you don't have to pay 3 entire soul hearts to get a mediocre item like lil' brimstone. You can instead get worse items like lil' delirium for *free*
In all seriousness though angel rooms have a good chance of giving you soul or eternal hearts and the items they give you are always free. The pool is also much smaller so good items are more likely to show up. On the contrary the items you'd want from the devil item are a much smaller percentage of the pool (I quickly went through the pool and found roughly 24 items that are almost always worth taking in either pool, only devil room pool is bigger).
I'm not saying only 24 of them are useful, I'm saying around that many are a must-take in most situations. More of them are good if you're playing a character with red hearts but blue baby gets super close to no health if you take early deals, unless you're so lucky that you get stuff like the pact, the mark, ceremonial robes, abaddon etc. on the second floor. An early 9 lives could also be good since you can sacrifice a life to get a free item if you have health laying around on the floor before you leave.
Of course stuff like mom's knife and brimstone are game-winning but most new players find it hard to not get hit, so it might not be worth it giving away 3 out of 4 hearts to get one of them.