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I'm not sure if you have any mods installed, but, I'd highly recommend downloading and using External Item Descriptions. This mod tells you about the items you're picking up.
I'd also like to suggest turning on the extra HUD options. I believe it's called "Found HUD" in the options menu. This shows you the items you've picked up + stats.
Learn how to find secret rooms easily, and use any extra bombs attempting to find them. Don't be afraid to spend your coins in the shop to gain any advantage you can.
Finally, don't be afraid to take early game Devil Deals, as they tend to increase your damage output, which ultimately will help.
1. Stay away from the doors, as Mom's Arm will reach out for Isaac.
2. Keep moving as Mom will constantly stomp down.
3. Kill enemies quickly and efficiently.
Do this and Mom will cease to exist in no-time.