What's the best combo?

[Bandu be liek]

Im new to this game (not really) but who knows the best combos here?

[squat_instructor]

vinegar + baking soda is a solid one

[Bandu be liek]

Originally posted by squat_instructor:

vinegar + baking soda is a solid one

Thanks!

[The deadly Cutsman]

Almond milk + ipecac

[DEAN (MORTGAGE PAYED)]

BRIMSTONE + IPECAC + LUSTY BLOOD + 20/20 + ABADDON + EYE OF BELIAL + REVELATION + ROCK BOTTOM + SOY MILK + SAUSAGE + PSY FLY + INFAMY

[The Renderer]

Up, Up, Down, Down, Left, Right, Left, Right, B, A, Start

[ploeppsel605]

theres not a the one best combo. One of my favorites is glitter bomb + dr fetus (especially if you go to the chest)

[UwU]

breakfast + dinner

[deconverge]

Lacryphagy + Eye of belial. best duo ever

[Senator Jim Death]

One of the big things the game is built around is its goofy synergies, and because there are hundreds of items that show up with weighted randomness I don't know if offhand there's a list of "best" combos--especially since your ability to choose what items you get is pretty limited, so it's usually just a matter of, at best, "will this new item help or hurt my current run?" Most ways to replace items that you currently have in your build select the item to replace or the item you get at random or replace specifically the last one or two things you've picked up, and that's not a very flexible way to advantageously tweak your build. Since there are so many combinations, it's probably simplest for most people to just look up in the wiki what effect a new item will have on their current run with respect to synergies, rather than to have extensive lists of item combinations to try for. Of course, when you have things like Tainted Isaac or Spindown dice or More Options or There's Options that give you many extra choices between items, you're going to be doing a lot of looking things up.

What comes up more often is what specific upgrade types are good for what characters. That's things like how homing is good for low-health characters, which lets you focus on dodging because you can fire somewhat blindly, and also for characters with Brimstone-style attacks because can help get more of the beam's damage area onto more enemy hitboxes than just firing straight beams. Of course, that's really just a simple two-part synergy where you have mostly or entirely in control the first part of the synergy (which character you choose).

[Lucifer ★✬]

anything with brimstone, be it homing shots, controlled shots, etc

tech .5 is also verry nice

Originally posted by deanTV (F2P) 馳驰 马 / 馬 ho:

BRIMSTONE + IPECAC + LUSTY BLOOD + 20/20 + ABADDON + EYE OF BELIAL + REVELATION + ROCK BOTTOM + SOY MILK + SAUSAGE + PSY FLY + INFAMY

just list all the op items why not, lol

[JellyPuff]

Aside from typical gamebreaking combos, like Habit+Scapular+Cursed Skull shenanigans or Blank Rune+Jera, i'd say Pyromaniac+Dr.Fetus. Aside from certain (challenge) character-specific gimmicks, i can't think of any situations, where this combo isn't an auto-win. Effective invincibility and boss armor means nothing to you. There's a reason, that Pyromaniac is extremely rare.

Originally posted by UwU:

breakfast + dinner

This guy repents.

[Senator Jim Death]

Originally posted by JellyPuff:

Aside from typical gamebreaking combos, like Habit+Scapular+Cursed Skull shenanigans or Blank Rune+Jera, i'd say Pyromaniac+Dr.Fetus. Aside from certain (challenge) character-specific gimmicks, i can't think of any situations, where this combo isn't an auto-win. Effective invincibility and boss armor means nothing to you. There's a reason, that Pyromaniac is extremely rare.

Originally posted by UwU:

breakfast + dinner

This guy repents.

Pyromaniac + Dr. Fetus is extremely strong, but characters who don't get red health can be killed by attrition, and while it's powerful protection for the Lost or Tainted Lost I'd think Host Hat + Dr. Fetus is slightly better for them for survivability. Infinite self-damage-capable explosive anything with Pyromaniac is very strong for characters with red health, even if it's something like No. 2 where the explosions happen slowly--and what about Kamikaze + Pyromaniac for those characters?

[Чучмек.]

Chocky milk + haemolacria

[Danizk0]

Glowing Hourglass with anything that allows you to use it more frequently effectively turns you into a clairvoyant, I felt like the main character from Katana Zero when I got Sharp Plug with it

[Bulborb]

Polaroid on ???, T.Bethany, T.Judas, T.Forgotten, and T.???