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Tainted cain - honestly you can just run through and suck up everything and get random items and end up fine. On the Platinum God website there is a bag of crafting list where you can input your own combos and search for items based on name/what you find..
It's hard to answer this question as it depends on what you get.
When it comes to late game bosses it can be a little rough. This is why creating a large army and also banking that red health is important. Saving a sun card or full health pill for hush or the other late game bosses lets you amass 1-2 extra groups of clots if they do manage to die to a projectile pattern that isn't very dodgable. The only time I would really use the sumptorium is if you know a pattern will destroy a lot of clots. But never use it if the amount of clots you suck up will surpass the amount of red health you have otherwise those extra clots you made will just go to waste outside of the one free clot you get for over healing. You can also just suck up the clots by running into a corner of the screen in certain situations to body block them.
I did lose a run to mega Satan one time. But other than that the character is so insanely powerful that you really should be able to steam roll the run once you get that initial momentum. She is definitely rough on the first couple floors if you get very few red hearts. But there are a ton of items that are super insane on the character like holy shot since it can activate on every single clot.
I gave some explanation how that works above. Typically very bad idea as you can delete a massive amount of clots using sumptorium wasting a ton of time and resources.
As for 2, the D20 should be first on your priority list. It's extremely easy to craft and you can use the Bombs you'll get from item pedestals to bomb the Donation Machine several times and reroll the resulting pennies for lots of pickups.
Then, get Sharp Plug, so you can convert the health pickups you get into charge for the D20 and keep repeating its rerolls to create whatever you need.
From there you want to try and segway into making Mom's Key, because the D20 will produce chests that Mom's Key will dramatically enhance for massive pickup generation.
You can also consider getting Birthright along the way for momentum, as it increases pickup yield from pedestal items. More pickup generation items like Fanny Pack, Piggy Bank, etc are definitely advisable.
And now, you can make your build into genuinely anything you want as long as you have enough time on your hands. I like crafting Candy Heart at this point, so while I'm gamebreaking I'm ALSO passively getting random stat boosts without having to think about it.
While you're doing this though, two words of warning;
-Craft an explosion immunity item or, preferably, search the trinket pool with Mom's Box for Safety Scissors. This stops troll bombs from damaging you and, in safety scissors' case, stops golden troll bombs from being a nuisance.
-Avoid ANYTHING that could potentially give you a pickup absorbing effect, magnet effect, etc. This includes Soul of Lilith, Cambion Conception, etc. You'll want your pickups static, not going anywhere. If you screw up and get a Dark Bum stealing all your hard earned hearts, start crafting Sacrificial Altars until you kill the bastard.
Order does not matter
I was fortunate that the alabaster box cheese got patched out while I was in the middle of my final tainted cain unlock. Pretty tedious character to do if you don't wanna sit there making items for hours and learning the optimal way of doing it.