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Obviously you're not going to be able to defeat all enemies after they spawn, it's a test of your ability to dodge multiple things at once. Press the button if you're starting to get overwhelmed. If you have invincibility frames, you can even touch it for free.
Money loss from button presses is negligible, you're only going to miss out on 1 penny if you press it. Feel free to pause during regular waves and don't be afraid to push the button if the first boss is tough.
Stats >>> health. You don't need health if you can kill everything before it hurts you. Buy soul hearts instead of health ups, you'll get some red health from silver item rooms anyway.
The second phase is actually much easier than the first one. Ultra Greedier is very predictable, try to look at his patterns next time you get to him. He only has ~4 attacks.
I recommend restarting until you get a dps upgrade in the first silver item/curse room. Greedier is a dumb gamemode, but it's not nearly as hard as it may initially seem.
Just kill things. Anything in front of you, and as many things as you can. Try to prioritize the enemies that keep you on the move so you can position yourself better for the less aggressive enemies. Don't worry about beating the timer between waves. You won't. Thinking at all about the timer will do nothing but frustrate you. Just kill the enemies as they come.
This is where luck comes into play. There's more ways to potentially get money than just the coins that drop from waves. Blow up machines, beggars, and nickel keepers, open any accessible chests you can, check your curse room if you're able. Don't press the button to stop waves, because it's never worth it. And again, just hope RNG is in your favor and you get good items to clear the room better.
It's not too hard a choice; always choose stats over health early on if you have the option. Stacking your stats will eventually make health a non-issue, because more things will die without having a chance to hurt you. No amount of stacked health will make up for low stats. Consider not even going into your first-floor devil room. If you completely clear the first floor, and then not go through the open devil room door, then the final room on the second floor will be an angel room, guaranteed. Items in those rooms don't cost health, are free, and can potentially be good enough to make a run. And if you manage to get a game-winning run early enough, then you can bulk up on health to make Ultra Greed less stressful in the end.
Ultra Greed is not a fun fight at all, which makes it all the more important that you go into it as strong as possible from previous floors. I find Phase 2 easier than Phase 1, though. Just hug the wall and move away when he jumps, kill bombs that are close to you and let ones that are close to him explode and hurt him, don't stand directly in front of the door lasers. The fight looks hectic, but it's really not. Not after all the times I've done it, anyway.
It all pretty much depends on you having a good start and running into good items. Isaac doesn't really care how good at the game you are or how many hours you've sunken into it. Every run is ultimately defined by the items you find.
I have tried playing the mode a couple times in the past and then never again. Had I known what possible way I could beat it with the pre-Repentance characters I would've not posted this thread. Now that I have beaten it once with a very powerful character I don't see how any other could even compare to the damage Tainted Lilith can output. Azazel used to be really good but since the Brimstone nerf he hasn't been nearly as useful.
I don't see how a character firing regular tears can even finish the first couple of floors without a huge lack in health or practically no damage/firerate items due to all the healing/health ups required to keep yourself alive.
Firstly, there are 8 waves and pausing between each wave takes away one coin if I understand the Greedier Mode mechanics correctly; how am I losing only 3 pennies by doing this? Besides, 3 pennies is already significant (if you do this every floor), as you're only getting 12 from regular mob waves and then some from the bosses. Then, you barely have enough to get an item and a key for a second item, where is the money to heal yourself up coming from? How will you be able to continue pressing the button? Are you expected to flawlessly beat every single wave?
Soul hearts are not always available, and when they are they cost 5 pennies. If you buy one you may not be able to purchase an item (especially if you've been pressing button and haven't managed to accumulate enough wealth due to the lesser payout), or may have one less key at your disposal. Correct me if I'm wrong, but I was under the assumption your priority would actually be getting items to power up instead of spending money in a desperate attempt to keep yourself alive (later floors are practically impossible to beat without tear/damage ups).
Honestly if I'm still sitting at base damage and almost no tear ups by the third floor I'm restarting because at that point the waves will just get crazy and you'll either be worn down or you'll get bored.
1-hold R like an idiot until you get a good starting item
2-hold R like an idiot until you get Humbling Bundle / Steam Sale on the shop,
or
3-hold R like an idiot until you get a 7c stat upgrade in the shop.
Well holding R until you get damage isn't cheesing it because you still have to get through the rest of the floors. It's just pointless to start for some folks because you CAN get into dry spells and not have damage and in this mode it's not like normal mode where you can clear each room and ONLY have to deal with that room. Greed mode you have to deal with a room, then if you can't deal with that room another is thrown at you, and then another, and another, and another. So holding R here shouldn't be looked upon like you're being an idiot. It's just so you're not wasting your time. If my initial shop doesn't have any damage ups or at least good tears up items I'm restarting.
And yes. Everyone who says to 'git gud', which there aren't any in this thread mind you, probably did that because I don't care how good you are at some point you're going to not be able to handle all the enemies the game throws at you without decent items at some point. No need to be hostile about it.
Most of it comes down to getting a good devil/angel room item that lets you keep up, either the devil deal on the first floor if you have red hearts to take stuff, or skipping it for a guaranteed angel deal on the next floor. Any average tears or damage item should allow you to survive the first two floors just fine and get the deals going so feel free to hold R for a minute or two for a decent starting item or keys in the curse room.
Once your damage is capable of handling the rest of the floors prioritize HP ups if there's no spirit hearts, if there is a spirit heart for sale stack up on a bunch of them. It's a lot more valuable than yet another damage upgrade towards the end, especially since Ultra Greed has boss armor.
As for Ultra Greed, there's a trick to the second phase that makes it a cakewalk. Just move between the corners of the room in a clockwise motion, moving to the next corner every time you see him jump at you, while firing away at him of course. This will result in him rarely firing anything at you and you being safe from the brimstone doors, 95% of the time he'll just keep jumping. Sometimes the rhythm will be broken if he goes to pick up coins on the floor, but it's not too hard to get him back into it.
An exploit that litterally made Greed mode easy (not sure if you can do it now from posts I read on some changes)
You may be able to use the dice to change your coins into items if you kept them on the floor. In this case those coins can become chest to open in which you can open to gain more items on the floor which you can keep doing. Some of the gold chests may even contain power ups. however your most likely going to be able to get max coins keys and bombs pretty easy and along with that the ability to get a lot of power ups until it only starts dropping powerups. Also if your lucky to get a steam sale and the item to duplicate all the items you could duplicate a steam sale to to have free shops. Like someone stated which I believe this was something they might have changed in Repentance by one of the posts I read recently so you may not be able to do it anymore.
In addition to Steam Sale now being multiplicative instead of additive, rock waves no longer count as explosions.
Don't exclusively stick to Greedier try the the story mode and unlock some stuff, then come back to Greedier mode. The shuffle of items will also be better(not always though).
One item is equal to 3 soul heats. If you're on death's door, you should obviously take the health even if there is a damage up ready to be bought. Don't hoard keys, there's always going to be at least one in the shop, and it might be on sale. If keys on your floor cost 3c and there's nothing better to buy, you can take an additional one for the next floor, but if that's not the case, leave it and buy it on the next floor.
On the last floor, spend your remaining money on soul hearts if you're low on health or items if you're not confident in your dps.
So are the pennies now not considered the same damage against host hat and pyromaniac? forgot about rockwave being able to deflected by them.