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3 familiars (3 freezer babies are good) for conjoined + tractor beam + jacob's ladder
it's really cheap and easy to make and is powerful :)
If you want a 100% winning strategy: craft echo chamber, any spawning card, D20, the end.
Craft Mom's Box and hope for a "Strange Key" to do Hush even after 30 minutes (Although this is unlocked by Defeating ???, Isaac, The Lamb and Satan with Tainted Eve.)
Craft Mercurius to rush through the doors.