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Its recommend to use Isaac for his D6. Don't re-roll the bombs though. then you wont have enough bombs to get in the secret room. Etc..
Seed No.2: YONV-NAPF This run is also fairly as good as the first. You once again spawn right beside the treasure room. And you will get Polyphemus from it. This item is also game breaking and can carry the run!
Seed No.3: V4KF-3DWK At the start of the run you get blood of the martyr. This item is awesome. you get more damage ups overtime. On the first devil deal. You will get deaths touch..
Seed: TBEJ-NTJT
First treasure room mom's knife