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EDIT: got it to work. go into the binar folder for ME2 and right on the exe, compatability and say run as admin, then close that stuff, then exit steam and run steam as admin, works for me, should work for you guys, good luck
The issue has existed for well over a year now. From what I can tell, it is caused by the ME2 config tool in the game data. Running it causes some sort of corruption that breaks the game from launching successfully.
Although my copy is not the Steam version. I got mine as part of the ME Trilogy which (unfortunately) activated on Origin.
Supposedly non-Trilogy versions are unaffected by this. Friend of mine has it on Origin and he tells me it worked fine for him the last time he tried.
It has happened to quite a few other people as well, but EA and Bioware have made little to no response to the issue.
A little lense into the past:
http://answers.ea.com/t5/Mass-Effect-2/Mass-Effect-2-won-t-start/td-p/237368/page/4
According to this thread, it's been a problem for years now. I'm amazed there isn't much news about this case of poor game support.
http://answers.ea.com/t5/Mass-Effect-2/Mass-Effect-2-does-not-launch/td-p/2095527
Just a simple rename of binaries.
This worked for me, thanks my dude.