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BUT (<- and that is a big but):
The difficulty is to decide when to leave. If you need to heal or rebuild modules after waves its best to leave. If the waves don't cause you problems, continue exploring, even on the highest floors. You get hit by a bad EMP? Leave if you can.
Usually up to floor 7 or 8 opening every door isn't very difficult (except when you get a really bad layout or a bad combination of monsters).
After that, considering what to do should happen with every door. With bosses around "normal" waves can suddenly pose a threat.
Always take into account that your next door might just give you another unlit room and trigger the maximum amount of enemies. Can you deal with that?
So, general rule: Open as many doors as you can, but leave before it's to late.
All right so decide what to do based on what's happening. Thank you, I thought there was a general rule or a meta
Even better: Open a bunch of doors, pick up crystal, buy everything at a dust merchant ... then run. Double bonus for doing this with a solo hero.
... unless it's an Item. Then you do have time. Just run through those monsters on the way out, they can't stop you. Go ahead, you can always heal on the run. Is one more Item worth -5 food for a heal? Sure it is! What could possibly go wrong?
... says everybody, once each. Whee!
It might seem silly to mention, but of course, if it's Floor 12(i.e. the last floor in a non-Drill Pod run), then all you need to care about is making a safe path to the exit. Burn all the Industry you need to(within reason), to keep Silic Zoners at bay while you try to gain more Dust. Keep an eye out for Major Module slot rooms along the way, which can be powered by Emergency Generators if needed to cover your escape. Sell all your extra items to a Dust Merchant if you find one. There's no longer any reason to save anything for the next floor, because there are no more floors.
Use them to defend the elevator room for 1 full minute \o/
Other things to take into considerations are many research cristals, obviously risk of dying if you slip up and if you have more than 4 items, it could be worth it to explore further until you find a merchant to sell your items you can't take with you.