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If you're in stealth, I find it's better to not rush the transmission, yes it might take longer, but you're not buying every form of transmission. for instance Bacteria only need Air, Water and Birds. Anything else just speeds it up. Buy resistances when necessary, but don't over buy. Watch what is necessary (bacteria for instance stalls in the cold, but no the hot, buy cold resistances not hot).
You have a limited number of DNA, so what's important is spreading, once that ball is rolling, lay off it unless it needs a push. from there, you start killing when you have enough, and make sure you have enough to get that going as well.
H*CKIN AGGRESSIVE
The DNA you earn during the game depends on your severity. If you play with no symptoms at all, you get very little DNA, and then you can't afford symptoms when you need them.
So I guess that you play with no symtoms at all while you are infecting ?
Take Rash, Abcesses and skin lesions at start, and don't devolve your free mutations. Your game will be balanced very differently.
Being noticed is not a problem, they won't work hard on you if your symptoms mostly give infectivity. The problem is not the cure, it's that you are too slow. That is why the cure has the time to win.
Also, there is a several month delay between the moment you pay for symptoms, and the moment when you really have you lethality set. So the moment to take lethal symptoms is sooner than the moment to really go lethal badly.
It worked with bacteria, in a small difficulty level, to win in a bad score. At long term it's wrong, first because it impeaches you to learn how to play, and second it won't work for the other plagues or in hard difficulty levels.
Of course they will work harder on you if you have much severity, but only very lethal symptoms really increase your severity. Infecting symptoms like rash, abcesses, skin lesions, coughing, sneezing, sweating, vomitting, diaorrhea will give you enough severity to be spotted, but not enough to make humans work hard on you before you will have infected several billions of people.
But still, they will work on you when they will understand that you are running the infect all the world, so you mustn't let much time between the moment you are getting billions of infected and the moment they are really falling. So it means that :
1) You have to take lethal symptoms like organ failure before the last sane human is infected.
2) You mustn't create very late countries by doing mistakes, like not fixing your start setting penalties, as you would kill faster than you keep infecting them at the end.
Yes, more severity makes bubbles (orange ones too) give more DNA. And probably random DNA too, not only bubbles. Only the special bubble from the start country in multiplayer is not affected by severity.
But I don't know exactly the relation because the relation depends on the moment of the game.
A small severity at start will be enough to get 2 DNA instead of 1, as at the very begining it's normal to have a moderate severity. Whereas by the end of the game, you will need much higher severity to get loads of DNA.