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Since I haven't messed around with contagion yet, I can't offer any suggestions for good mixes though.
The real power, however, comes with Contagion + Essence Drain. Both Chaos damage, so ES and Reflect mean nothing to them. And Contagion spreads Essence Drain.
For chaos-resistant enemies, and bosses (and especially chaos resistant bosses) toss in a spell totem with Wither, and perhaps Temporal Chains.
But on it's own, Contagion is very, very fast casting with minimal animation and fair AoE. So you can toss it at a huge swarm of mobs as you sprint desperately in circles, kiting. Every 5 seconds or so, you toss a new one, and you'll eventually kill them all. Not 'time effecient' but effective. And if you're playing in Hardcore, that can really start to matter, as it will let you tear down overwhelming odds, so long as they dont' manage to stun or freeze you as you kite them.
My current link now is Contagion + Void Manipulation + Controlled Destruction. Can I add any gem to make it better? It only has 496 dot at the moment.
The totem is not going to ramp the damage enough to warrant ONLY totem casting it unless you are actively avoiding damage and running away, which is always a possibility. My point is that it's okay to have wither on a totem, but don't forget to self cast when able, as it really does ramp your damage.
If you cast your two spells, contagion / essense drain, you can then spell echo / faster casting / increased duration spam wither, and if you can get close to 20 stacks, you are talking about the damage increasing upwards of 140% increased damage!
Some other things to link to contagion could be faster casting to cast it faster, increased duration, and rapid decay. Another good one would definitely be "increased Area of effect" or if you're crazy, concentrated effect. Concentrated effect would technically be better against bosses, but not much else, so i don't recommend that. Rapid decay gives a "more" multplier of 20% damage at the cost of 15% reduced duration - but that 15% can easily be fixed via skill nodes or running increased duration.
HOpe this helps!
i linked it with
contagion
+increased aoe
+increased duration
+ whatever, i have void manupulation for a little bit more dmg
essence drain
+void manipulation
+rapid decay
+ controlled destruction
for 5l empower, no thoughts for 6l, dont have any.