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http://pathofexile.gamepedia.com/Chaos_Inoculation
While CI handsomely deals with poison it does not remove the single one drawback of energy shield.
And Zealot's Oath (Life Regen applies to Energy shield
are 2 good ways to keep energy shield up. And since Energy shield can get over 5k pretty easily, and over 10 k not out of the question (seen multiple peope with over 14k) it's fairly popular. Life cannot get that high, ever. The items to trade for are expensive, though
Generally for a CI build, atleats as I understand it, you are pretty much dependent on ranged damage (spells) and evasion, with the premise being that you clear through enemies quicker than they can chip away at your energy shield. Building defensively in this case is not a good idea... You'll want to be building offensively so that fights are quick and the chances of being hit are fairly limited.
This is wrong in so many ways.