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I'd say most good ante-8 builds are compatible with more than one hand, even if they do have a favorite hand. (Maybe deep infinite builds aren't, like the thing I saw on the wiki using a hundred negative planets with the voucher that turns them into mult multipliers.)
but two pair and pair made me win the red game(i was stuck for 5 hours)
Flush is probably the most reliably accessible 5-card hand. With some builds, that might be important - stuff with heavy per-card effect jokers (like Fibonacci Hack or Hiker) or an extremely upgraded deck where you've got red seal polychrome glass cards or something. Though there you may wind up tending towards the Five Flush rather than just Flush.
Some examples from my unseeded runs today for comparison:
Cleared ante 8 easily with a two pair build mostly thanks to an early burnt joker and two blueprints a little later. Came grinding to a halt in endless mode due to a 300M blind despite two pair upgraded over lvl 50.
Run just completed: started hearts flush thanks to a duped bloodstone, worked towards a high card build with polychrome, red seal, steel kings. With 2x barons, mime, blueprint, mindstorm, consistently scoring ~ 2.0e25 by playing a single card. Cleared ante 18 (~ e30 score) thanks to a serpent boss and a cryptid, pushing my highest score to 6.773e46.
I don't know about you, but I like numbers so big I can't comprehend them.