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A somewhat recent (last rebalance) two card combo I found is Photograph with Hanging chad, two commons for 2x x 3 mult and you can manipulate when that mult is applied with face card positioning.
Or the classic Midas Mask + Vampire. Even though, it's been nerfed, it still spirals out of control, if you get the combo somewhat early.
Canio + Glass Joker scales so incredibly fast. Every destroyed glass face card scales both, and the glass boost itself is still powerful.
Baron + Mime, for obvious reasons.
I really enjoyed getting Egg (+3 sell value every round) very early and then adding Swashbuckler (multiplier = sell value of all Jokers) to it. I had some insane multiplier going on SB that then was also influenced by a couple negative joker slots and multipliers. That's the run that got me the 1 million in a single hand achievement.
Another one I only managed to pull off once and I can't even remember the joker names because I take them so rarely -- the one that adds stones to your deck combined with the one that gives you a chip bonus for every stone. Can get some really big chip counts with that combo.
Of course if you keep your eyes peeled you'll find synergies in unexpected places which makes it fun to play around with jokers that you normally wouldn't.