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hopes this helps someone else out there
Thank you so much. The DXSETUP.exe did it for me.
I ran vcredist2010_x86.exe, repaired the install, ran PhysX-9.12.0613-SystemSoftware.msi (it told me my version was newer) and ran the DXSETUP.exe in the DirectX folder. Then I updated my PhysX by updating my GeForce GameReady Driver ( now version 441.41). At last I reinstalled the game. Of no avail.
And Jack Keane is not the only game which is not running anymore: Spellforce and DragonAge Origins are also affected, although I cannot say with certainty that they aren´t running by the same cause...