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Also don't be afraid to check the shop each time after a run and equip pretty much any weapon. It makes a huge difference even if its a white item.
You must be talking about Elites, and those only spawn like every few minutes. I'm skeptical that if you're on D0, that you could be so weak that you can't kill any of the elites before the next Elite or boss spawns.
Try out Merris with Warped Shot + Gem High and never look back.
Twins at 7 minutes. Necromancer at 14 and Baron at 20. There are two mini hordes of slimes at 4 and shields at 17 but you should be 1 shotting those enemies.
If you do a bad build and pick bad I guess the green slimes could cause you a problem. Early on.