There are mods to get this to work on Windows 10 and Multi-Core Fix

[craigsters]

https://steamcommunity.com/sharedfiles/filedetails/?id=244272720 Multi-Core Fix for Fallout 3 ^^^--- see this guide it helps and works

There's a mod that well get the game to work with Fallout Script Extender (FOSE) it's called see link below

Fallout Anniversary Patcher

https://www.nexusmods.com/fallout3/mods/24913?tab=posts&BH=3 once you use this mod Fallout Script Extender (FOSE) well work again , mod author gives youtube link on how to use mod , video below https://youtu.be/9D9QTzezKRQ?si=0Az1nGPL8YXWx3eD

Other features of the Fallout Anniversary Patcher

Features

Downgrades the game from October 2021 update (1.7.0.4) to 1.7.0.3 which is widely supported by other mods, most notably FOSE

Removes Games for Windows Live (xlive.dll is no longer loaded by the game) and removes LIVE button from the main menu

Makes the game 4GB aware

Automatically loads FOSE when using Fallout3.exe to start the game (if FOSE is installed)

Fixes a file handle limit and mod limit bug
New in 1.1: Fixes a crash when using Intel graphics cards to run the game

from mod author of Fallout Anniversary Patcher sticky comment

Always run the game once through Steam/GOG after installing it to generate .ini files!
Vortex users: Install FOSE 1.3b2 manually in Fallout 3 folder after patching, do NOT use a suggested "Fallout Script Extender" option in Vortex!

Once you do all this, launch the game from either Steam library or the games exe, using Fose to launch wont work properly anymore

I did all the above yesterday and got about 39 mods to work, I briefly played tell the baby crawled to the father, but well be playing more today

owe I'm also running the game in compatibility mode as admin and you can also switch it to either Vista or XP service pack 3, mine was set for Windows Vista, not sure if the downgrade fix or Anniversary Patcher did that, so I left that alone and only did the admin settings

Feel free to re-wright this in a better explanation if it helped you

[Dr. Merkwürdiglieben]

I got problems to get it to even start on Win 11.

i followed the above advice +
this video:
https://www.youtube.com/watch?v=vV71FYGD2eE

I'll tinker around with it later, but right now I'm pretty pissed...
This all worked well on XP and now years later I've to screw around with this game like it's from DOS Box again.

[craigsters]

I have it running with Windows 11 fine, I forgot to check the boxes for all mods and just did that, I got ArchiveInvalidation Invalidated! to work too

And the funny thing was that NVAC - New Vegas Anti Crash https://www.nexusmods.com/newvegas/mods/53635/?tab=files works with Fallout 3 and Skyrim

[Dr. Merkwürdiglieben]

Originally posted by craigsters:

I have it running with Windows 11 fine, I forgot to check the boxes for all mods and just did that, I got ArchiveInvalidation Invalidated! to work too

And the funny thing was that NVAC - New Vegas Anti Crash https://www.nexusmods.com/newvegas/mods/53635/?tab=files works with Fallout 3 and Skyrim

Will try his again later.