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Abomination is most likely the most powerful skill in the tree. As any kind of poison char you have to get it. Once you have it you will see why. It makes fights with large crowds of enemies a joke.
Play around with the devotion tree on grimcalc. Try different builds and if you are not happy with your choices in the game you can still respec the devotion points and choose something else.
Here's an example of the devotions I use for my DEE Warlock:
- Scorpion (Curse of Frailty) - Rat - Viper - Sailor's Guide - Spider - Wendigo (Bloody Pox)
- Manticore (DEE) - Oklaine's Lantern - Behemoth (Possession) - Abomination (Sigil of Cons)
(All listed constellations are complete except the back leg of Manticore and the right arm of Abomination)
It increases the explosion radius and damage of each eye and provides some reduced enemy physical damage, but gives it a 4-second cooldown.
Not recommended if you want to be a caster with DEE as your main attack.