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1. I'm in one of the rogue-like dungeons (Steps of Torment, Bastion of Chaos, Port Valbury) and I want a bigger margin of error, if you will. Usually, I'd pop an HP pool and regeneration pots for that.
2. I'm fighting a Nemesis and I want to make the fight less tedious. HP pool and regen and/or reduced freeze duration in this case.
3. My damage output is lacking: it happened exactly once, against Van Aldritch (screw that mofo, lol).
Resistances and Defensive Ability ae super important in this game, you can't neglect them especially if you're using melee. Glass cannon should also have plenty of Attack Damage Converted to Health to stay alive. As for Undead they deal all damage types except for aether and poison. What I tend to do is carry several accessories (rings, amulets, medals) with different resists on them and swap them depending on the area I'm in.
bleed and poison is damage over time, you see them as debuffs on right bottom of the screen. there are bleed pools as well.
ranged enemyes are supposed to do pierce damage. melee ones mostly do phisical.
for particular unit damage types you can always look it up in the wiki.
personally i never use ressistance potions becose i find it redundant you should have ressistances on your items, most of the time maxing them out in ultimate shouldn't be a problem, before that you can manage with ~50% in elite and ~30% in veteran. (elemental and poison ressistances are good to keep as close to 80% as possible, even in veteran)
if you get oneshot you probably have too little hp and maybe armor. phisical damage is most common after all. you do need as much defences as possible. damage means nothing if you run around not attacking or just die.
around lvl 50 you should have around 4k-8k hp depending on your classes and items. you need healing options either way(preferably multiple). if you play something like shaman wendigo totem can keep you alive for quite a while and getting 6k hp should be quite easy due to the aura shaman gets.