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(1) Teleport to Lower Crossing, clear the outside area and the Burial Cave
(2) Teleport to the Secret Laboratory and clear the area backwards
(3) Rush to the room right before Warden Krieg and clear the area
You can get Tainted Brain Matter from the Warden and any hero you kill on the way, including Valdaran, if you have reached Nemesis status with the Aetherials.
In order to acquire dynamite other than by crafting, just run the Four Hills areas. There are several spots with guaranteed drops plus a lot of spots with a high chance of dropping dynamite. Money Bags Martin also drops at least one piece of dynamite.
These areas have the advantage that you don't have to deal with Aetherial ground effects.