So the game will work, if you are using a Nvidia GPU then this should get you working. Master Squid posted this in the Community Discussion page and if it works for you then drop off on his profile and hit him up with an award. After the patching with this stuff i have had 0 issues with it running.

This is just a remaster of the NES version with some much needed upgrades like being able to swap weapons in game and bringing all radios to each sector. There is secrets in some levels that will net you a 1up or weapon upgrade. Each weapon has 1 upgrade. The practice levels are a whole other game on its own nearly, you unlock more as you progress through the game and find them.

Originally posted by Master Squid:

Chances are the game starts up and then crashes displaying a Physx Error. This is because you're computer lacks the required Physx Drivers. For this you will need to go to the Physx page here > https://www.nvidia.com/en-us/drivers/physx/9_12_1031/physx-9-12-1031-legacy-driver/

If you're like me and have more than 4 cores, your game probably doesn't like your CPU, so you'll have to manually replace the exe. with a functioning one found here https://www.pcgamingwiki.com/wiki/Bionic_Commando_Rearmed

Download the file listed on that website and then go to the bionic commando folder in your steamapps and delete the original exe. file and replace it with the new one.