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Python isn't very useful for Freyna since the debuff doesn't do much in the long run. Fallen Hope as of now is not useful at all compared to the first two Ultimate weapon I listed.
I do highly recommend getting Fallen Hope and Python in your collection just for the off chance they get buffed in the future.
I have it maxed out and use it exclusively on my Freyna but secret garden is the better choice.
With maxed out Unique perk, it only has 40% chance to activate the poison spread while requiring you to have the enemy poisoned. May as well have a good gun that can do double duty as a boss DPS weapon and mob killer rather then just a gun that could occasionally do something.
A well built Freyna will kill low tiered enemies with her DoT, bigger enemies will already be poisoned from those effected by her 1/Trauma Room 0. The Explosion damage is very negligible, it doesn't even do as much as Thundercage.
Fallen Hope does not even copies/spread the poison from Freyna abilities. It make a new poison DoT which is weaker when it spreads.
As stated before, have one in your collection just in case Fallen Hope gets buffed when Ultimate Freyna release but if you need something to use now, go with Secret Garden and Enduring Legacy. They will serve you better then Fallen Hope in it current state.
Fallen Hope only saving grace is that it is easy to farm for compared to the other two weapons.
The best weapon for Freyna currently is Secret Garden, but it's possible that this changes for Ultimate Freyna when she gets released on October 10.
Otherwise, it increases the cost of your skills which is no fun. Starts at +20% Skill Cost then goes down 5% with each upgrade, until no skill cost increase at 4/4.