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The Sentinel is almost identical to the Handgun so both work but the Sentinel has a bit of a fire rate boost, a bigger overall clip, while only having very very little less dmg (like 0.1 iirc) at max upgrade. Meanwhile, it has simply flat out superior stats at low upgrade further making it preferably over Handgun.
These are both some of the cheapest weapons to upgrade in the game, too. In fact, you can max all 3 levels of all categories before the end of chapter 3 on either of the two pistols if you loot enough its that affordable.
The main reason you want it though is the special after fully upgrading grants it a critical chance boost of 5x which means it has a significantly higher chance of instantly killing a target (if it spawns a las plagas it works on that just like heads, too). This scales with harder difficulties even further while dmg goes down in value as enemy hp goes up in harder difficulties... further biasing towards the two pistols.
Afterwards you can either go the knife, or if you like the bolt action sniper over the semi-auto sniper rifle you can upgrade that next as you will have spare money... or you can simply save the money for later weapons after you finish the handgun.
The Semi-Auto rifle and Riot shotgun are going to be arguably their best options for those weapon classes.
shotgun power
pistol
everything else
for weapon get punisher for 5 spinels until you get red9 ( free in chapter 4 )
if you want buy weapon i recommend get rifle first ( you can get free scope ) for faster kill chainsaw guy
Then use pistol for normal enemies.
Shotgun/Rifle for strong enemies.
I also went with the crossbow thing but it feels weird cause it fills out the same role as the handgun and was stuck with 100 handgun ammo after a while lol.
You find a better pistol pretty fast at the lake so dunno if upgrading handgun is worth it but the game even tells you that you get almost everything back you invested in a note before you go to the lake so you are not meant to hold back.
Why wasting precious spinels on a bad gun that hardly deals more damage? You dont need the penetration either as enemies have no defense so if they are clustered up just shotgun it.
Red9 is probably bottom tier in professional. Top tier in standard and assisted difficulty.
"The main reason you want it though is the special after fully upgrading grants it a critical chance boost of 5x which means it has a significantly higher chance of instantly killing a target"
In the original even with the crit you did not dealt enough damage on the hardest difficulty, I wonder if this is still the case here thats why everyone said Red9 back then unless you play on normal.
To the main question - Knife, S9 dmg if dlc owned, any shotgun all, c9, after you get stock. And BUY RIFLE. It helps a LOT. Crossbow on hard is total ♥♥♥♥. Full dmg up 6 arrows in head to kill a regular enemy. Just in what world this is stealth weapon?
I have a strong feeling that higher dmg now comes with better stugger.
For the pistol its mainly used for headshots where it will instant kill so the dmg isn't very important and at worst the dmg is only half the red 9. Usually for enemies that aren't being instant killed via crit such as chainsaw, bosses, etc. you're going to use shotgun/sniper (and much later for some magnum). Thus the dmg figure is usually not relevant by the time you reach the point where the red 9 is finally acquired and then starts to get more dmg. Its basically like 25~50% crit chance so you instant kill in around 1~4 bullets on avg.
The Red 9 is actually strongest on lower difficulties where dmg is more valuable as enemy health scales down where at higher difficulties enemy health scaling goes up but weapons don't do more dmg so the value of instant kills via crit increases even though crit chance isn't changing further.
For the oddball enemy with armor you can usually just swap to a sniper and headshot them, and even line them up for multiple headshots if you want.
As an example lets say the Red 9 does 5 dmg at max while the Handgun/Sentinel 9 (I'll just call handgun here) does 2 at max. Red 9 has 5~10% crit rate while Handgun has 25~50% and crits = instant kill.
If normal enemy has 20 HP on standard then...
Red 9 will kill it in 4 hits and almost never crit it.
Handgun will also kill it in 4 hits or LESS (as low as 1).
The winner is quite clear.
Now lets assume they got 35 HP on a harder difficulty later in the game...
Red 9 kills it in 7 shots...
Handgun kills it still in 4 or LESS shots on average.
Winner is even more clear here.