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My condolences.
Sins of a Solar Empire's various versions are all quite compatible with Wine: http://appdb.winehq.org/objectManager.php?sClass=version&iId=25711.
A lot of Mac ports of games are actually just Wine-based shells that contain the original, unmodified Windows program. If you're technically savvy, there's no reason why you couldn't strip a shell of its game and try to insert another game, but your mileage will vary depending on the game's Wine compatibility and how much of the original Wine code was changed or left out of the shell.
If you don't want to bother with the technical details, Crossover, a commercial port of Wine to OSX (and Linux, though I don't know why you'd use it in that case over Wine), should do nicely. Note that it will cost you quite a bit, there's a price to pay for convenience.
Anyone who says gaming on OSX is impossible probably has never tried or is not technically savvy enough to fiddle around with Wine. I still prefer Ubuntu derivatives over OSX though, OSX hides way too much stuff way too deep for me to feel comfortable using it.