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Agica was the original faction available during early access, newer players there thought the counter mechanic was too complicated. TBF tainted ones got a nerf to their basic defense and Sora also got a changed in here initial Onslaoughts that made her a lot tougher to play.
Final fight I end up with 30 viruses on that one.
Thanks for sharing. I will point out that your video was from before version 1.0 and many cards you are using were more powerful. Just the fact that your Cursed Vigors blocked more damage than they do now (and could be upgraded to block 17!) is pretty significant. Still, it's a useful video, but I'm not sure how possible it still is to reliably hit 15+ virus, although Jokan is probably the best to do it with.
Regarding the first character, her virus also doesn't provide persitent benefits, like the other two. Stack 8 viruses (difficult to get to and manage) to get a one-time bonus. VS counterattack that's always available. Or effects that activate every round you get a virus while also not having to stack them. All of this indeed is odd.
I enjoy the game, but utterly avoid the virus faction. Too many hoops to jump with lesser payoff.
I did it on both my last Jokan runs with the 2 Guild Companions after both nerfs to defends, I did not streamed those runs prioritizing the Guild on those, I did a recent Sora/Bot one though, I usually share end decks under the strategy thread in the Discord Channel, and yes is usually just a Jokan thing.
Yeah, as I said, it seems like only Jokan can pull this off. I've tried both of the other two virus heroes and they both had trouble getting high on the virus meter and the decks were much harder to manage than Jokan.
All in all, the virus mechanic just seems a bit off...unless you're playing Jokan (who is crazy powerful).
To OP's point, I don't think the ideal way to go is to try and have 10+ viruses in your deck. That's a high-risk strategy that doesn't pay off for 2 reasons IMO: First, your draws become terrible, because there are so many viruses in your deck, and second, the card benefits unlocked by high virus counts don't quite compensate, especially at the current game difficulty where having one dead turn will ruin you.
I'd say the way to go is to have anywhere from 4 to 8 viruses, depending on the cards you have and the power of your character - mainly Sora, I think it's her sweet spot. You also have to pay attention to cards that offer deck manipulation of viruses - such as moving to discard, moving/adding to draw pile/erasing.
If you can trim the basic cards from your deck, you can minimize the impact of unwanted viruses in hand by tossing them from draw to discard or vice versa without actually polluting your hand, and reaping the benefits that the cards provide for doing so.
Also, when upgrading, prioritize card draw. Bigger hand, more consistency.
In any case, I've had most success with Sora, including my only winning run.
Red robot dude had me consistently blowing past 15+ Virus every fight from Floor 2 onward the one time I played him, and it wasn't hard to win that run either. Just gotta stay hyper aggressive and punch everyone to death before they can punch you first!
I mention above a couple of times that it only seems possible with Jokan (the red robot dude). With the other two heroes, it feels like hitting 15 virus is extremely difficult, and not worth the effort even if you do. It almost feels like the virus meter goes to 15 just for Jokan, which seems odd.
I tried Issandre for the first time last night, and you're definitely right that she doesn't hit large Viral loads anywhere as effortlessly as Jokan, but I was still making it to Cobalt 3 in all my Boss & Elite fights from Floor 2 through the end. You do so with different tempo and play patterns, but it was overall still a desirable goal and far more bonus than malus to have my deck filling up with Virus.
In regards to your OP, I'm teaching my wife how to play as we speak, and I set her up with the 1st Counter gal + 3rd Counter King dude as companion because I do agree that play mechanic is more easily readable for a first playthrough. I don't think the Virus decks are that much more difficult though, and having Rocks in your deck with +/- factors is already a fairly standard deck-builder genre trope. The biggest issue Virus presents for a new player is that the upsides to filling your deck with poison rocks isn't immediately apparent if you don't already know which cards could appear in later drafts to benefit from them. The Hero Cards give a bit of a hint towards that at least, and with a bit of assumptive Meta knowledge I figured pretty quickly that these were just another set of resources to manipulate, but perhaps there's more that could be expressed directly from tooltips / pop-ups.
Regardless, I think the Virus clan is overall incredibly powerful and I haven't had any trouble winning with them. They're certainly far less mechanically complex when compared to the Sad Knight or any of the Gunslingers!