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I can answer like one or two of those relatively quickly. Carlo is Gepetto's son that grew up in the Monad Charity House because G was too busy to be a dad. Carlo died during a big bad thing that happened there and Gepetto tried to forge a heart to contain Carlo's soul and put it in P (whom he crafted) until he could use it to bring Carlo back... At least that's my understanding.
And the God of Ergo would, in turn, be a God of Life and Death.
Sophia is the daughter of the previous alchemist leader, Valentius, and she has the keen ability to manipulate ergo; she was imprisoned once Simon took over. She also has the ability to manipulate time, which may be relevant to ergo as well. The death screen is very likely canon in this context. Simon seems to damn Pinocchio for having been beaten by "The Blue Fairy's Gift". This could be a reference of her manipulating ergo oooor he's well aware of Pinocchio's numerous deaths to him and Sophia turning back time until he's beaten.
Aside from Sophia, the person that seems most in tune with ergo is Geppetto, likely moreso than the Alchemists. He knows how to apply it to technology and is responsible for creating puppets and their morality: The Grand Covenant. This doesn't seem to be the result of ergo being a natural hivemind; Geppetto can directly program who follows the Grand Covenant and who doesn't, since he states he didn't tie you to it.
That's pretty much how I interpret it all. Don't have all the sources since some information is in text outside of item information, and that's a bit harder to find.
At least that's what I'm pretty sure anyway from scrapping through all the books. The wiki is so knew that it can be hard to track down lore atm or find confirmation on theories.
My basic understanding of the setting's plot is that at some point in the distant past, an unknown object crashed nearby to where the town of Krat was, or would be built. This crash site would later come to be know as the Relic of Trismegistus. From the crash site, the condition known as the Petrification Disease lurked, which gradually claimed the lives of an unknown number of people and/or animals, creating the initial stockpile of Ergo. The Petrification Disease works by crystallizing the very lifeforce of a person, creating an energy source of incredible power, a la Fullmetal Alchemist. Sometimes, some or all of a person's ego will survive the crystallization process, seemingly at random when not controlled.
Much later, Ergo is discovered, and the early Alchemists start to research the substance and its properties, including eventually subjecting willing and unwilling subjects to the Petrification Disease in order to create more Ergo. Gepetto also becomes instrumental in the creation of puppets, using Ergo as their power source. Shortly thereafter, the lucky, or unlucky, few who managed to partially survive the crystallization start to appear, leading the Alchemists to discover the 'first' living puppet, a maid who saved a baby using her own free will. This causes the Alchemists to redouble their efforts, and focus on using the power of Ergo to attain immortality, because that always ends so well. At some point through here, the Alchemists become less scientists and more cultists, some even going so far as to worship Ergo.
A wide variety of experiments were carried out by the Alchemists, leading to certain test subjects developing strange powers, such as Simon Manus' ability to read minds, Sophia's power of time, and that one test subject's ability to 'read' Ergo by eating it. All these experiments also gave rise to the Carcasses. I'm not quite sure what specifically distinguishes the Carcasses from 'normal' victims of the Petrification Disease, but it seems linked to the increasing amount of waste material the Alchemists were generating in their experiment with Ergo. Still later, Simon Manus rose to power within the Alchemists, and decided that he would go one step beyond attaining immortality, and become a god, using the 'Arm of God'. The game proper occurs during his attempts to do so, coinciding with Gepetto's attempts to retrieve his son Carlo from the dead, using the puppet rampage and P to do so. Simon also creates a new generation of Alchemists more akin to monsters, such as Laxasia and Victor. By the very end, Simon actually succeeds in becoming a god, but is killed by P before fully 'hatching'.
Meanwhile, elsewhere in the world a cabal of superhumans are none too pleased with the Alchemists, and send one of their agents, Paracelsus, to investigate the situation and retrieve the arm of god if possible.