Helpful things...

[entropy008]

...not properly explained in-game (or maybe I missed it)

1) Variants of a given building (eg Pharmaceutical Laboratory, Pharmaceutical Testing Laboratory) can be selected by hovering the mouse over the given building in the UI and choosing one vs. the other.

2) One does not need to connect trails/ skyways all the way to a given city/ colony. It's only necessary to connect the above to an existing trail/ skyway that is connected to the a given city/ colony.

3) If one chooses (spoilers/) the Stalwart path to maximize the generator, it is necessary to TURN OFF Surplus Injectors in order to build an oil stockpile and transfer oil to Winterhome. (/spoilers).

4) Multiple copies of a given building can be built in a given district. Eg you can fill every Logistics District with Automated whatever-it's-called and have a max transport of 3,600 between New London and a given colony.

5) Always plan multiple districts with one or two hexes free for placement of helpful hubs.

6) One cannot do anything with (spoilers/) the oil found at the Old Dreadnought until the Council is built. (/spoilers)

Anything else, feel free to add!