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If you can pick up any orbs with multiball (Matryorbshka being ideal), I was able to get first-turn-wins against the Dragon and Minesweeper bosses by having enough of the multiballs go down the X2 holes generated by the Weighted Chip relic. The Bad Cheese/Round Guard combo is a free win against that boss, RIP if you fight the wall boss in act 2 with it though. Orbs/relics that make pegs better are great here because there are so many pegs, Splatorb and Ballm being some of my favorites.
I won't make separate paragraphs for each decent relic/orb, but here are some that your build can benefit from in that specific fight that people might overlook: Kinetic Meteorite, Sand Arrows, Haglin's Hat, Peglinero's Pendant, Beckoning Crit. Prime Slime. And of course the generally good relics are good here too like Popping Corn, Duplication Station, and Pegbag.
Aside from that, just make sure you play this following normal Roguelike strategy such as; remove any orbs from your bag that don't synergize with your build, feel free to avoid taking a boss relic if they all would be bad for your build, spend gold wisely when upgrading your orbs since each upgrade after a fight makes the next upgrade more expensive, spend as little gold on healing after fights as possible, fights are a guaranteed source of gold while question mark spaces on the map aren't guaranteed to give you anything, some orbs benefit more from being upgraded than others so upgrade those first, you can return to the main menu to restart a room if you feel like you lost too much health or got a bad bag order.