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From what I've seen, the DoT damage from Poison and Rot only seem to be affected by the weapon/spell that applied the affect (Poison applied with a Venomfang Claw, for example will deal nearly twice as much damage per tick as poison applied by a Mist spell - total durations may vary though) and the maximum health of the enemy - higher health = more damage per tick.
I haven't seen much testing posted about the Rot effect but some people on the wiki comments at least have posted various tests for Poison.
Only scarlet rot ticks for a % of max health
Well, that wasn't true when I tested poison damage immediately before making the last post.
I hit several enemies with Mist, a Poison-infused rapier, and the Venomfang claws. On a rune bear in Limgrave, the Mist and Rapier poisoned for 9-damage per tick while the Venomfang hit for 17 per. Changing nothing, I used the same weapons on soldiers and dogs in Caelid - soliders ticked for 7 and 15 respectively and the dogs ticked for 8 and 16.
I can't say with 100% certainty that it's health-related but there's clearly some kind of variation between the damage done to different enemy types.
It's a DOT that deals damage as a percent of your total health per second. So how much total health you have doesn't matter, it will kill at the same speed.