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I also hate being limited to 3 powers at a time.
I never really messed around with that function.
I'd really like to use more variety of biotics, but I always feel like I need Overload and I'm really fond of Assault Drone as well.
So I'm typically 'stuck' with only Pull as a primer
If you use an assault drone, you might want to have at least one profile as an engineer.
The drone can also be specced to be either a primer or a detonator.
I never liked pull, Ive always preferred Singularity.
If you want to acquire a couple other biotic powers, Lance and Aegis are also fun. Lance requires manually aiming, but is good for dealing raw damage.
Aegis is mainly good against Annointed.
Charge is very fun but risky, as is cloaking.
Charge and cloak together is a very fun op combo.
While you can't directly command squadmates to use powers, they can still help with combos.
For example, you can couple overload with Drack's incinerate or Peebee's pull.
Last, you can always respecc in the medbay aboard the tempest.
The vanilla profiles are indeed quite useless. I suggest using the mod Favorite Swapping Overhaul on Nexusmods. It removes the cooldown, so that essentially you have 12 powers you can use.
https://www.nexusmods.com/masseffectandromeda/mods/693
As for the profiles/favourites, they already have built-in hot-keys. The F1-F4 keys allow you to switch between them without needing to go through the Tab menu.
I find the cooldown between profiles makes them kind of pointless. My fights are usually over before the cooldown wears off anyway.