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It will never decrease your stats, at worst, it can be like you don't have the blessing at all (at 100%)
Well, in an extended run, you can use it until you start the boundless stages - just replace it with another blessing. However, if you have Lone Wolf activated, do not select Overconsumption as you will not be able to replace it.
What nul says is also true. With Mysterious Jokul enabled, you can replace it in Act 4.